FBXO5 and TPM3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FBXO5	TPM3
Description		F-box protein 5	tropomyosin 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Meiotic Spindle	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Ligase Inhibitor Activity	Molecular_function Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Oocyte Maturation Regulation Of DNA Replication Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of DNA Endoreduplication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence Negative Regulation Of Response To DNA Damage Stimulus	Muscle Contraction Actin Filament Organization Muscle Filament Sliding
Pathways		SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription	Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Phenethyl Isothiocyanate
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)	Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		16 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDK1 EVI5 FZR1 SKP1 SRC TPM3 UBE2C UBE2S	44 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 DVL2 FAM9C FBXO5 HDDC3 HOOK2 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 NOD2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P
Entrez ID		26271	7170
HPRD ID		09348	01840
Ensembl ID		ENSG00000112029	ENSG00000143549
Uniprot IDs		Q9UKT4	A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753
PDB IDs		2M6N 4UI9	6OTN
Enriched GO Terms of Interacting Partners?
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