KLHL3 and SYT2

Number of citations of the paper that reports this interaction (PubMedID 10734137)
26

Data Source:
HPRD (in vitro)

		KLHL3	SYT2
Description		kelch like family member 3	synaptotagmin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Membrane Cell Junction Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Exocytic Vesicle
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Inositol 1,3,4,5 Tetrakisphosphate Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Ion Homeostasis Selective Autophagy Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Membrane Organization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Toxicity of botulinum toxin type B (BoNT/B) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Botulinum Toxin Type B
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		16 interacting genes: AKT1 CFAP206 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA SYNCRIP SYT2 WNK1 WNK3 WNK4	5 interacting genes: KLHL3 NRXN1 STON2 SYNCRIP WNK1
Entrez ID		26249	127833
HPRD ID		09011	02520
Ensembl ID		ENSG00000146021	ENSG00000143858
Uniprot IDs		Q9UH77	Q8N9I0
PDB IDs		4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?
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