LDLRAP1 and PSD4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		LDLRAP1	PSD4
Description		low density lipoprotein receptor adaptor protein 1	pleckstrin and Sec7 domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Vesicle Membrane Recycling Endosome	Membrane Cleavage Furrow Ruffle Membrane
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	ARF Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding
	Biological Process	Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Membrane Organization Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Regulation Of ARF Protein Signal Transduction
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252) Platelet count ( 27863252) Total cholesterol levels ( 28334899)	Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		9 interacting genes: AP2B1 APP C6orf58 CLTC LDLR LRP2 MAPK8IP3 PSD4 TFAP2A	2 interacting genes: LDLRAP1 USP9X
Entrez ID		26119	23550
HPRD ID		05765	15191
Ensembl ID		ENSG00000157978	ENSG00000125637
Uniprot IDs		B3KR97 Q5SW96	Q8NDX1
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?
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