LDLRAP1

Description		low density lipoprotein receptor adaptor protein 1
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GO Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Vesicle Membrane Recycling Endosome
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Membrane Organization Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
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Diseases
GWAS		Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252) Platelet count ( 27863252) Total cholesterol levels ( 28334899)
Interacting Genes		9 interacting genes: AP2B1 APP C6orf58 CLTC LDLR LRP2 MAPK8IP3 PSD4 TFAP2A
Entrez ID		26119
HPRD ID		05765
Ensembl ID		ENSG00000157978
Uniprot IDs		B3KR97 Q5SW96
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?
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