RCHY1 and UBASH3B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RCHY1	UBASH3B
Description		ring finger and CHY zinc finger domain containing 1	ubiquitin associated and SH3 domain containing B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity	Protein Tyrosine Phosphatase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Signal Transduction Peptidyl-tyrosine Dephosphorylation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Protein Binding Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 24097068 25961943 20686565) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) HDL cholesterol ( 24097068 20686565) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		69 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA2 HOXB1 HOXB5 HOXC4 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	27 interacting genes: CBL CBLB CUL3 DAZAP2 DMRT3 DOC2A FAM168A JAK2 KHDRBS1 MAP3K1 PKP4 PRKN RCHY1 RNF41 SHC1 SLC25A48 SPRY2 SYK UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B
Entrez ID		25898	84959
HPRD ID		07607	16463
Ensembl ID		ENSG00000163743	ENSG00000154127
Uniprot IDs		Q96PM5	Q8TF42
PDB IDs		2JRJ 2K2C 2K2D	2CPW 2E5K 5VR6 5W5G
Enriched GO Terms of Interacting Partners?
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