HECTD1 and SCFD1

		HECTD1	SCFD1
Description		HECT domain E3 ubiquitin protein ligase 1	sec1 family domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Membrane Golgi-associated Vesicle Cis-Golgi Network Cytosol Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Protein Binding Syntaxin Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Heart Valve Development Ventricular Septum Development Aorta Development Anatomical Structure Development Protein K63-linked Ubiquitination	Cell Morphogenesis Response To Hypoxia Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Vesicle Docking Involved In Exocytosis Response To Toxic Substance Protein Transport COPII Vesicle Coating Regulation Of Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Toxin Transport Negative Regulation Of Autophagosome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	COPII-mediated vesicle transport
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 29566793 27455348) Cognitive decline (age-related) ( 28078323) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: HRAS HSPB1 IGSF1 KHNYN MTNR1B SCFD1 UBE2D2 UBE2D3 UBE2L3 YWHAG	6 interacting genes: DLST HECTD1 PPBP STX5 USO1 USP22
Entrez ID		25831	23256
HPRD ID		17098	10210
Ensembl ID		ENSG00000092148	ENSG00000092108
Uniprot IDs		Q9ULT8	B7Z5N7 B7Z738 Q8WVM8
PDB IDs		2DK3 2LC3 3DKM
Enriched GO Terms of Interacting Partners?
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