FTH1 and DAXX

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		FTH1	DAXX
Description		ferritin heavy chain 1	death domain associated protein
Image
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Cytosol Intracellular Ferritin Complex Autolysosome Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body PML Body
	Molecular Function	Ferroxidase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding SUMO Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Immune Response Negative Regulation Of Cell Proliferation Neutrophil Degranulation Negative Regulation Of Fibroblast Proliferation Oxidation-reduction Process	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Sodium Arsenite
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events
Drugs		Iron Dextran Iron
Diseases
GWAS		Estradiol levels ( 22675492) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)	Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		35 interacting genes: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 NTAQ1 PACSIN1 PCBP1 PCBP2 PIAS4 SDCBP SIRPA SOX5 SPP1 STAT1 TICAM2 TOLLIP TRAF4 UBR1 YWHAE	91 interacting genes: ACVR2A AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 MAP3K5 MCRS1 MDM2 MEN1 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RIPK3 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TCF3 TCF4 TCF7L2 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBC UBE2I USP7
Entrez ID		2495	1616
HPRD ID		00615	04424
Ensembl ID		ENSG00000167996	ENSG00000204209
Uniprot IDs		A0A024R525 P02794	A0A024RCS3 B4E1C1 Q53F85 Q9UER7
PDB IDs		1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0 4OYN 4Y08 4YKH 4ZJK 5CMQ 5CMR 5GN8 5GOU 5JKK 5JKL 5JKM 5N26 5N27 5UP7 5UP8 5UP9 5VTD 5XB1 5YI5 5ZND 6B8F 6B8G 6FTV 6GSR 6H5I 6H6T 6H6U 6IPC 6IPO 6IPP 6IPQ 6J4A 6J7G 6KE2 6KE4	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?
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