DAXX and TGFBR2

Number of citations of the paper that reports this interaction (PubMedID 11483955)
105

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		DAXX	TGFBR2
Description		death domain associated protein	transforming growth factor beta receptor 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body PML Body	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Membrane Raft
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding SUMO Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Activin-activated Receptor Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Sodium Arsenite	Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia In Utero Embryonic Development Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Tricuspid Valve Morphogenesis Cardiac Left Ventricle Morphogenesis Endocardial Cushion Fusion Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Notch Signaling Pathway Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Response To Steroid Hormone Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Secondary Palate Development Response To Cholesterol Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Proliferation Involved In Endocardial Cushion Morphogenesis Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Lens Fiber Cell Apoptotic Process MiRNA Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events	Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases
Drugs			Glycerin
Diseases			Colorectal cancer Loeys-Dietz syndrome (LDS) Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Breast cancer ( 29059683 23535729) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cognitive decline rate in late mild cognitive impairment ( 26252872) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Migraine ( 22683712 27322543) Migraine - clinic-based ( 23793025) Night sleep phenotypes ( 27126917) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systolic blood pressure ( 30224653) Tonometry ( 17903302)
Interacting Genes		91 interacting genes: ACVR2A AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 MAP3K5 MCRS1 MDM2 MEN1 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RIPK3 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TCF3 TCF4 TCF7L2 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBC UBE2I USP7	46 interacting genes: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML PSMD14 RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TDGF1 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		1616	7048
HPRD ID		04424	01823
Ensembl ID		ENSG00000204209	ENSG00000163513
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	A3QNQ0 D2JYI1 P37173
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O	1KTZ 1M9Z 1PLO 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5QIN 5TX4 5TY4
Enriched GO Terms of Interacting Partners?
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