MAFF and PRRX1

Number of citations of the paper that reports this interaction (PubMedID 11036080)
12

Data Source:
HPRD (in vitro)

		MAFF	PRRX1
Description		MAF bZIP transcription factor F	paired related homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion	Nuclear Chromatin Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Coactivator Activity HMG Box Domain Binding
	Biological Process	In Utero Embryonic Development Transcription By RNA Polymerase II Parturition Blood Coagulation Skeletal Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Neuronal Stem Cell Population Maintenance
Pathways		Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Birth weight ( 31043758) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)	Atrial fibrillation ( 28416818 28416822 29290336 29892015 22544366) Blood protein levels ( 29875488) Early onset atrial fibrillation ( 28460022) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196 25673412) Intraocular pressure ( 29617998) Ischemic stroke (cardioembolic) ( 29531354) Macular thickness ( 30535121) Male-pattern baldness ( 29146897 28196072) Prevalent atrial fibrillation ( 28416818) Response to angiotensin II receptor blocker therapy ( 22566498) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ATF3 BACH2 BATF2 BATF3 DDIT3 FOS GTF2A1L HDAC5 HOXD12 MAFG MAFIP NFE2 NFE2L1 NFE2L2 NFIL3 NR3C1 NRF1 OVOL1 PPARG PRRX1 PSAP SUN2	6 interacting genes: ATP1B1 GTF2I MAFF MAFG SOX10 SRF
Entrez ID		23764	5396
HPRD ID		05343	01337
Ensembl ID		ENSG00000185022	ENSG00000116132
Uniprot IDs		Q9ULX9	P54821
PDB IDs
Enriched GO Terms of Interacting Partners?
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