RYBP and CBX2

Number of citations of the paper that reports this interaction (PubMedID 10369680)
68

Data Source:
HPRD (in vitro, in vivo)

		RYBP	CBX2
Description		RING1 and YY1 binding protein	chromobox 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		28 interacting genes: ABL1 CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A YY1 ZFP42	15 interacting genes: DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP2-4 KRTAP4-12 MDFI PCGF2 PHC2 RBMY1A1 RBMY1F RNF2 RYBP
Entrez ID		23429	84733
HPRD ID		09607	14397
Ensembl ID		ENSG00000163602	ENSG00000173894
Uniprot IDs		Q8N488	Q14781
PDB IDs		3IXS	2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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