CNOT1 and CNOT9

Number of citations of the paper that reports this interaction (PubMedID 24768540)
97

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CNOT1	CNOT9
Description		CCR4-NOT transcription complex subunit 1	CCR4-NOT transcription complex subunit 9
Image
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Multicellular Organism Development Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Gene Silencing By RNA Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Nuclear Receptor Transcription Coactivator Activity
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		12 interacting genes: CNOT2 CNOT3 CNOT4 CNOT8 CNOT9 DDX6 NANOS3 PPARG RARA RXRA THRB TNRC6B	8 interacting genes: AKT1 CNOT1 CNOT4 EGFR GIGYF1 GIGYF2 GRB10 MYB
Entrez ID		23019	9125
HPRD ID		11999	08828
Ensembl ID		ENSG00000125107	ENSG00000144580
Uniprot IDs		A5YKK6	D5MQE1 Q92600
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA	2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON
Enriched GO Terms of Interacting Partners?
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