SORCS3 and IDE

SORCS3

IDE

Description sortilin related VPS10 domain containing receptor 3 insulin degrading enzyme
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention deficit hyperactivity disorder ( 30478444)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Depression ( 29700475)
  • Diabetic kidney disease ( 26305897)
  • Diastolic blood pressure ( 30224653)
  • Feeling miserable ( 29500382)
  • General factor of neuroticism ( 30867560)
  • General risk tolerance (MTAG) ( 30643258)
  • Intelligence (MTAG) ( 29326435)
  • Major depressive disorder ( 27479909)
  • Medication use (calcium channel blockers) ( 31015401)
  • Medication use (diuretics) ( 31015401)
  • Metabolite levels ( 23823483)
  • Mood instability ( 31168069)
  • Multisite chronic pain ( 31194737)
  • Non-alcoholic fatty liver disease activity score ( 31311600)
  • Rosacea symptom severity ( 29771307)
  • Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775)
  • Systolic blood pressure ( 30578418)
Interacting Genes 2 interacting genes: IDE NGF 12 interacting genes: APP AR BRDT IGF1 IGF2 INS NR3C1 PEX5 SLC28A2 SORCS3 UBC UCHL5
Entrez ID 22986 3416
HPRD ID 12100 00894
Ensembl ID ENSG00000156395 ENSG00000119912
Uniprot IDs Q86XB2 Q9UPU3 A0A3B3ISG5 B3KSB8 P14735
PDB IDs 2G47 2G48 2G49 2G54 2G56 2JBU 2JG4 2WBY 2WC0 2WK3 2YPU 3CWW 3E4A 3E4Z 3E50 3H44 3HGZ 3N56 3N57 3OFI 3QZ2 4DTT 4DWK 4GS8 4GSC 4GSF 4IFH 4IOF 4LTE 4M1C 4NXO 4PES 4PF7 4PF9 4PFC 4QIA 4RAL 4RE9 5CJO 5UOE 5WOB 6B3Q 6B70 6B7Y 6B7Z 6BF6 6BF7 6BF8 6BF9 6BFC 6BYZ 6EDS 6MQ3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?