SCAP and INSIG2

Number of citations of the paper that reports this interaction (PubMedID 12242332)
144

Data Source:
HPRD (in vitro, in vivo)

		SCAP	INSIG2
Description		SREBF chaperone	insulin induced gene 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding	Protein Binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)	Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS			Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		12 interacting genes: ATG16L1 DHX30 HIPK2 INSIG1 INSIG2 KLHL18 LAMC2 NDUFAF3 PGRMC1 SEC24B SREBF2 WDR6	9 interacting genes: LMNA PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP
Entrez ID		22937	51141
HPRD ID		03300	16361
Ensembl ID		ENSG00000114650	ENSG00000125629
Uniprot IDs		B7Z6H0 Q12770	A0A024RAI2 B4DQ23 Q9Y5U4
PDB IDs			4J82
Enriched GO Terms of Interacting Partners?
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