INSIG2 and RNF5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		INSIG2	RNF5
Description		insulin induced gene 2	ring finger protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Ubiquitin Protein Ligase Activity
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Response To Insulin SREBP Signaling Pathway Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Ubiquitin-dependent Protein Catabolic Process Response To Bacterium Negative Regulation Of Autophagy Ubiquitin-dependent ERAD Pathway Protein Destabilization ERAD Pathway Cellular Protein Catabolic Process Transmembrane Transport Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Endoplasmic Reticulum Mannose Trimming Regulation Of Autophagosome Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)	Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Idiopathic membranous nephropathy ( 21323541) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) Waist circumference ( 31453325) Waist circumference variance ( 31453325)
Interacting Genes		9 interacting genes: LMNA PSMA7 PSMB1 PSMC3 PSMC5 RNF5 SCAP SREBF2 VCP	34 interacting genes: ABHD16A CFTR CYB561 CYB561A3 FHOD1 GLP1R INSIG2 JKAMP MAVS MPDZ PXN RNF185 SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM242 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z YIPF2
Entrez ID		51141	6048
HPRD ID		16361	04057
Ensembl ID		ENSG00000125629	ENSG00000204308
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	A0A024RCQ4 Q99942
PDB IDs		4J82
Enriched GO Terms of Interacting Partners?
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