FCGR2A and CRP

Number of citations of the paper that reports this interaction (PubMedID 10675363)
39

Data Source:
HPRD (in vivo)

		FCGR2A	CRP
Description		Fc fragment of IgG receptor IIa	C-reactive protein
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding IgG Binding	Complement Component C1q Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium Negative Regulation Of Blood Vessel Diameter Regulation Of Interleukin-8 Secretion
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis	Classical antibody-mediated complement activation
Drugs		Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab	N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases		Systemic lupus erythematosus	Systemic lupus erythematosus
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)	Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 24763700 29403010 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Interacting Genes		14 interacting genes: BLK CRP CRYAB FYN GP6 GRB2 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1	21 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70
Entrez ID		2212	1401
HPRD ID		00906	00422
Ensembl ID		ENSG00000143226	ENSG00000132693
Uniprot IDs		P12318	P02741
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6	1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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