FCGR2A

Description		Fc fragment of IgG receptor IIa
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding IgG Binding
	Biological Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation
Pathways		FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases		Systemic lupus erythematosus
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)
Interacting Genes		14 interacting genes: BLK CRP CRYAB FYN GP6 GRB2 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1
Entrez ID		2212
HPRD ID		00906
Ensembl ID		ENSG00000143226
Uniprot IDs		P12318
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?
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