EPS15 and DNM2

Number of citations of the paper that reports this interaction (PubMedID 11483962)
24

Data Source:
HPRD (in vitro, in vivo)

		EPS15	DNM2
Description		epidermal growth factor receptor pathway substrate 15	dynamin 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane Postsynapse Glutamatergic Synapse	Golgi Membrane Phagocytic Cup Photoreceptor Inner Segment Cell Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Postsynaptic Density Microtubule Cytoskeleton Membrane Lamellipodium Axon Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Ruffle Membrane Protein-containing Complex Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Cadherin Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding D2 Dopamine Receptor Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Protein-containing Complex Binding WW Domain Binding Nitric-oxide Synthase Binding
	Biological Process	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization	G2/M Transition Of Mitotic Cell Cycle Mitochondrial Fission G Protein-coupled Receptor Internalization Ventricular Septum Development Regulation Of Transcription, DNA-templated Golgi To Plasma Membrane Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Signal Transduction Spermatogenesis Response To Light Stimulus Positive Regulation Of Lamellipodium Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Receptor Internalization Transferrin Transport Regulation Of Rac Protein Signal Transduction Aorta Development Response To Cocaine Positive Regulation Of Apoptotic Process Macropinocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Organelle Fission Synaptic Vesicle Transport Neuron Projection Morphogenesis Positive Regulation Of Phagocytosis Regulation Of Synapse Structure Or Activity Regulation Of Nitric-oxide Synthase Activity Coronary Vasculature Development Membrane Organization Membrane Fusion Cellular Response To Carbon Monoxide Cellular Response To X-ray Cellular Response To Nitric Oxide Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Non-motile Cilium Assembly Cellular Response To Dopamine Regulation Of Golgi Organization Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription
Drugs
Diseases			Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood urea nitrogen levels ( 31152163) IgE grass sensitization ( 22036096) PR interval ( 30046033)	Bipolar disorder ( 31043756) Height ( 25429064) LDL cholesterol ( 21347282)
Interacting Genes		51 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL OPTN PPT1 PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8	57 interacting genes: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DNMT1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1L GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 NTAQ1 PDE6G PFN1 PPIB PSTPIP1 PTK2 RHOU RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 XIAP ZBTB16 ZFAND6
Entrez ID		2060	1785
HPRD ID		08968	03852
Ensembl ID		ENSG00000085832	ENSG00000079805
Uniprot IDs		B7Z240 P42566	P50570 Q8N1K8
PDB IDs		1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2	2YS1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?