DNM2 and MPHOSPH6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		DNM2	MPHOSPH6
Description		dynamin 2	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Photoreceptor Inner Segment Cell Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Postsynaptic Density Microtubule Cytoskeleton Membrane Lamellipodium Axon Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Ruffle Membrane Protein-containing Complex Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding D2 Dopamine Receptor Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Protein-containing Complex Binding WW Domain Binding Nitric-oxide Synthase Binding	RNA Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitochondrial Fission G Protein-coupled Receptor Internalization Ventricular Septum Development Regulation Of Transcription, DNA-templated Golgi To Plasma Membrane Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Signal Transduction Spermatogenesis Response To Light Stimulus Positive Regulation Of Lamellipodium Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Receptor Internalization Transferrin Transport Regulation Of Rac Protein Signal Transduction Aorta Development Response To Cocaine Positive Regulation Of Apoptotic Process Macropinocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Organelle Fission Synaptic Vesicle Transport Neuron Projection Morphogenesis Positive Regulation Of Phagocytosis Regulation Of Synapse Structure Or Activity Regulation Of Nitric-oxide Synthase Activity Coronary Vasculature Development Membrane Organization Membrane Fusion Cellular Response To Carbon Monoxide Cellular Response To X-ray Cellular Response To Nitric Oxide Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Non-motile Cilium Assembly Cellular Response To Dopamine Regulation Of Golgi Organization Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis	Maturation Of 5.8S RRNA RRNA Processing
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Bipolar disorder ( 31043756) Height ( 25429064) LDL cholesterol ( 21347282)	Leukocyte telomere length ( 31171785) Lung adenocarcinoma ( 28604730) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		57 interacting genes: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DNMT1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1L GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 NTAQ1 PDE6G PFN1 PPIB PSTPIP1 PTK2 RHOU RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 XIAP ZBTB16 ZFAND6	33 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSBP1 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		1785	10200
HPRD ID		03852	16111
Ensembl ID		ENSG00000079805	ENSG00000135698
Uniprot IDs		P50570 Q8N1K8	H3BNT4 Q99547
PDB IDs		2YS1	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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