TRIM65 and IFIH1

Number of citations of the paper that reports this interaction (PubMedID 28031478)
24

Data Source:
BioGRID (enzymatic study)

		TRIM65	IFIH1
Description		tripartite motif containing 65	interferon induced with helicase C domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Cytosol
	Molecular Function	Zinc Ion Binding	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Positive Regulation Of Autophagy	Detection Of Virus Response To Virus Viral Process Protein Deubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interferon-beta Secretion Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases			Type I diabetes mellitus
GWAS		Body mass index ( 29273807) Psoriasis ( 28537254) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260) Vitiligo ( 27723757 22561518)
Interacting Genes		11 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A	5 interacting genes: APP TRIM40 TRIM65 USP3 ZCCHC3
Entrez ID		201292	64135
HPRD ID		15569	09507
Ensembl ID		ENSG00000141569	ENSG00000115267
Uniprot IDs		Q6PJ69	Q9BYX4
PDB IDs			2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?
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