IFIH1 and ZCCHC3

Number of citations of the paper that reports this interaction (PubMedID 30193849)
8

Data Source:
BioGRID (pull down)

		IFIH1	ZCCHC3
Description		interferon induced with helicase C domain 1	zinc finger CCHC-type containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm
	Molecular Function	DNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Ribonucleoprotein Complex Binding	Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Detection Of Virus Response To Virus Viral Process Protein Deubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interferon-beta Secretion Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus MDA-5 Signaling Pathway Innate Immune Response Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Interferon-alpha Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	Activation Of Innate Immune Response Detection Of Virus Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of RIG-I Signaling Pathway
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases		Type I diabetes mellitus
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 17554260) Vitiligo ( 27723757 22561518)	Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		5 interacting genes: APP TRIM40 TRIM65 USP3 ZCCHC3	1 interacting genes: IFIH1
Entrez ID		64135	85364
HPRD ID		09507	15701
Ensembl ID		ENSG00000115267	ENSG00000247315
Uniprot IDs		Q9BYX4	Q9NUD5
PDB IDs		2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?
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