CRTC2 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 15454081)
246

Data Source:
HPRD (in vivo, in vitro)

		CRTC2	PPP3CA
Description		CREB regulated transcription coactivator 2	protein phosphatase 3 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome	Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Plasma Membrane Z Disc Slit Diaphragm Sarcolemma Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Cyclosporin A Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein-containing Complex Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Gluconeogenesis Viral Process Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Brain Development Aging Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Negative Regulation Of Chromatin Binding Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Calcium Ion Excitatory Postsynaptic Potential Peptidyl-serine Dephosphorylation Cellular Response To Glucose Stimulus Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Connective Tissue Replacement
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid
Diseases
GWAS		Age at first birth ( 27798627) Empathy quotient ( 29527006)	Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		9 interacting genes: MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 YWHAB YWHAG YWHAZ	31 interacting genes: AATK AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SOD1 STUB1 SYNJ1 UBE4B
Entrez ID		200186	5530
HPRD ID		12347	00234
Ensembl ID		ENSG00000160741	ENSG00000138814
Uniprot IDs		Q53ET0	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		4HTM	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
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