EDA and EDA2R

Number of citations of the paper that reports this interaction (PubMedID 11039935)
52

Data Source:
HPRD (in vitro)

		EDA	EDA2R
Description		ectodysplasin A	ectodysplasin A2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Multicellular Organism Development Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)	Balding ( 26926045) Male-pattern baldness ( 27182965 22032556 28196072)
Interacting Genes		15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A	7 interacting genes: C1QB CASP8 CEBPE EDA FADD TRAF3 TRAF6
Entrez ID		1896	60401
HPRD ID		02347	02230
Ensembl ID		ENSG00000158813	ENSG00000131080
Uniprot IDs		A0A0U5J797 Q92838	B2RBZ9 B4DQY6 Q9HAV5
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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