EDA and GIMAP5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EDA	GIMAP5
Description		ectodysplasin A	GTPase, IMAP family member 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Lysosomal Membrane Integral Component Of Membrane Multivesicular Body Membrane
	Molecular Function	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding GTP Binding
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A	7 interacting genes: APP CHPF2 EDA GRAMD2B LDLRAD1 LSMEM2 STX4
Entrez ID		1896	55340
HPRD ID		02347	16280
Ensembl ID		ENSG00000158813	ENSG00000196329
Uniprot IDs		A0A0U5J797 Q92838	A0A090N8P9 Q96F15
PDB IDs		1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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