ECT2 and MBD1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
46

Data Source:
BioGRID (two hybrid)

		ECT2	MBD1
Description		epithelial cell transforming 2	methyl-CpG binding domain protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Homodimerization Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Negative Regulation Of Transcription By RNA Polymerase II Methylation-dependent Chromatin Silencing Transcription By RNA Polymerase II Heart Development Aging Neuron Differentiation Response To Nutrient Levels Response To Estradiol Response To Cocaine Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Astrocyte Differentiation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		37 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2	25 interacting genes: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SP1 SUV39H1 TENM1 ZNF512B
Entrez ID		1894	4152
HPRD ID		11860	01133
Ensembl ID		ENSG00000114346	ENSG00000141644
Uniprot IDs		Q9H8V3	A8K654 B4DI41 B4DUR3 Q9UIS9
PDB IDs		3L46 4N40	1D9N 1IG4 4D4W 5W9Q 6D1T
Enriched GO Terms of Interacting Partners?
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