DSP and GRPEL1

		DSP	GRPEL1
Description		desmoplakin	GrpE like 1, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Chaperone Binding
	Biological Process	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Protein Folding Protein Import Into Mitochondrial Matrix Regulation Of Catalytic Activity
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Mitochondrial protein import
Drugs		Zinc Artenimol
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561) Idiopathic pulmonary fibrosis ( 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		30 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDH5 COL17A1 CSTA DES DSC1 EVPL GRPEL1 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM	8 interacting genes: DSP FAM184B FGFBP2 MED28 NKX3-2 SFTPB WBP2 XYLB
Entrez ID		1832	80273
HPRD ID		00513	07550
Ensembl ID		ENSG00000096696	ENSG00000109519
Uniprot IDs		B4DKX6 P15924 Q4LE79	Q9HAV7
PDB IDs		1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?
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