CYBB and NCF4

Number of citations of the paper that reports this interaction (PubMedID 11893732)
95

Data Source:
HPRD (in vivo)

		CYBB	NCF4
Description		cytochrome b-245 beta chain	neutrophil cytosolic factor 4
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GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum	Cell Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding	Protein Binding Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Defense Response Inflammatory Response Electron Transport Chain Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Ion Transmembrane Transport Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Response To Oxidative Stress Positive Regulation Of Catalytic Activity Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Oxidation-reduction Process
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29679657) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: ACTG1 CYBA IQGAP1 NCF2 NCF4 RAC1	10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		1536	4689
HPRD ID		02382	03289
Ensembl ID		ENSG00000165168	ENSG00000100365
Uniprot IDs		A0A0S2Z3S6 P04839	A0A494BZS1 Q15080
PDB IDs		3A1F	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?
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