NCAN and TNC

Number of citations of the paper that reports this interaction (PubMedID 9341124)
18

Data Source:
BioGRID (far western blotting)
HPRD (in vivo)

		NCAN	TNC
Description		neurocan	tenascin C
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix
	Molecular Function	Calcium Ion Binding Hyaluronic Acid Binding Carbohydrate Binding	Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Post-translational Protein Modification Cellular Protein Metabolic Process Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS L1CAM interactions NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1	Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Beta-D-Glucose Thiodigalactoside Hyaluronic acid
Diseases
GWAS		Bipolar disorder ( 24618891 31043756 21353194) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 19060911 26780889) LDL cholesterol ( 18193043 19060906 19060911 26780889) Nonalcoholic fatty liver disease ( 29385134) Schizophrenia ( 25056061 29483656 23974872) Triglycerides ( 18193043 19060906 19060911)	Blood protein levels ( 30072576 29875488 28240269) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)
Interacting Genes		7 interacting genes: CNTN2 HMGB1 L1CAM NCAM1 PTN TNC TNR	8 interacting genes: CNTN1 EGFR FN1 ITGA5 ITGB1 NCAN PTPRB RAB14
Entrez ID		1463	3371
HPRD ID		02897	01756
Ensembl ID		ENSG00000130287	ENSG00000041982
Uniprot IDs		A0A024R7M3 O14594 Q4LE67	B4E1W8 J3QSU6 P24821 Q4LE33
PDB IDs			1TEN 2RB8 2RBL 6BRB 6QNV
Enriched GO Terms of Interacting Partners?
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