TNC and CNTN1

Number of citations of the paper that reports this interaction (PubMedID 10103110)
11

Data Source:
HPRD (in vivo)

		TNC	CNTN1
Description		tenascin C	contactin 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix	Membrane Membrane Raft Extracellular Exosome Anchored Component Of Postsynaptic Membrane Anchored Component Of Presynaptic Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding	Protein Binding Carbohydrate Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Post-translational Protein Modification Cellular Protein Metabolic Process Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Cell Adhesion Notch Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)
Interacting Genes		8 interacting genes: CNTN1 EGFR FN1 ITGA5 ITGB1 NCAN PTPRB RAB14	13 interacting genes: CNTN2 FYN L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TNC TNR
Entrez ID		3371	1272
HPRD ID		01756	07189
Ensembl ID		ENSG00000041982	ENSG00000018236
Uniprot IDs		B4E1W8 J3QSU6 P24821 Q4LE33	A0A024R104 Q12860
PDB IDs		1TEN 2RB8 2RBL 6BRB 6QNV	2EE2 3S97
Enriched GO Terms of Interacting Partners?
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