ADRA1D and ADRA1A

Number of citations of the paper that reports this interaction (PubMedID 15525470)
3

Data Source:
HPRD (two hybrid)

		ADRA1D	ADRA1A
Description		adrenoceptor alpha 1D	adrenoceptor alpha 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Z Disc T-tubule Nuclear Membrane Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Identical Protein Binding	Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Apoptotic Process Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Aging Behavior Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Micturition Calcium Ion Transport Into Cytosol Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Pilomotor Reflex Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		Amphetamine Midodrine Cabergoline Dapiprazole Amitriptyline Alfuzosin Norepinephrine Mirtazapine Phenylephrine Promazine Prazosin Imipramine Chlorpromazine Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Phentolamine Ergotamine Tamsulosin Methoxamine Propiomazine Fenoldopam Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Carvedilol Doxepin Desipramine Terazosin Pergolide Bromocriptine Quetiapine Mephentermine Methotrimeprazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Silodosin Droxidopa Xylometazoline Perospirone Dosulepin Etoperidone Cirazoline Synephrine Tiapride	Amphetamine Midodrine Citalopram Ziprasidone Cabergoline Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Mirtazapine Phenylephrine Loxapine Promazine Dipivefrin Droperidol Prazosin Imipramine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Amoxapine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Nicergoline Tamsulosin Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergonovine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone R450 Epicept NP-1 Sertindole Mianserin Silodosin Asenapine Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Cirazoline Synephrine Niguldipine Tiapride
Diseases
GWAS		Paneth cell defects in Crohn's disease ( 28352666) Preeclampsia ( 23551011) Sense of smell ( 26632684)	Blood metabolite levels ( 24816252) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		8 interacting genes: ADRA1A FLNC LNX1 NOS1 SNTA1 SNTB1 SNTB2 SNTG1	10 interacting genes: ABR ADRA1B ADRA1D BMP1 CXCR1 CXCR2 FLNC NOS1 PPP1R9B RGS2
Entrez ID		146	148
HPRD ID		00079	00081
Ensembl ID		ENSG00000171873	ENSG00000120907
Uniprot IDs		B0ZBE0 P25100	B0ZBD3 P35348
PDB IDs
Enriched GO Terms of Interacting Partners?
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