MIPOL1 and MYLIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MIPOL1	MYLIP
Description		mirror-image polydactyly 1	myosin regulatory light chain interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways			VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Longitudinal alcohol consumption ( 26081443) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Tonsillectomy ( 27182965 28928442)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)
Interacting Genes		38 interacting genes: ARNT2 ATP5PO BEX2 BYSL CCDC33 CCT3 CDK18 CKS1B DGCR6 EAF1 EIF4E2 ENKD1 FAM161A FBF1 HAUS1 MAGEA6 MCM7 MFAP1 MYLIP NEBL PPP1R13B PRPF31 RBM41 RCOR3 RNF6 RPL10L RTP5 SCNM1 SMARCE1 SRPK2 SSX3 TCHP TTC12 UBE2K USH1C UTP25 ZGPAT ZNF688	18 interacting genes: AR CNPY2 CRK DAPP1 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B RASSF5 SRPK2 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR
Entrez ID		145282	29116
HPRD ID		06029	17621
Ensembl ID		ENSG00000151338	ENSG00000007944
Uniprot IDs		A8K735 G5EA54 Q4G0U7 Q8TD10	Q5TIA5 Q8WY64
PDB IDs			2YHN 2YHO
Enriched GO Terms of Interacting Partners?
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