MYLIP and CNPY2

Number of citations of the paper that reports this interaction (PubMedID 12826659)
20

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MYLIP	CNPY2
Description		myosin regulatory light chain interacting protein	canopy FGF signaling regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Negative Regulation Of Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Height ( 31562340) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		18 interacting genes: AR CNPY2 CRK DAPP1 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B RASSF5 SRPK2 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	3 interacting genes: APP MLXIP MYLIP
Entrez ID		29116	10330
HPRD ID		17621	12056
Ensembl ID		ENSG00000007944	ENSG00000257727
Uniprot IDs		Q5TIA5 Q8WY64	Q9Y2B0
PDB IDs		2YHN 2YHO
Enriched GO Terms of Interacting Partners?
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