CSF3R and CISH

Number of citations of the paper that reports this interaction (PubMedID 15470047)
14

Data Source:
HPRD (in vitro, in vivo)

		CSF3R	CISH
Description		colony stimulating factor 3 receptor	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation
Pathways		Other interleukin signaling Transcriptional regulation of granulopoiesis	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		Pegfilgrastim Filgrastim FavId Lenograstim
Diseases
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252)	Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025)
Interacting Genes		19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2	18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		1441	1154
HPRD ID		00737	03897
Ensembl ID		ENSG00000119535	ENSG00000114737
Uniprot IDs		Q99062	Q9NSE2
PDB IDs		1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?
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