ADORA1 and ATXN1L

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)

		ADORA1	ATXN1L
Description		adenosine A1 receptor	ataxin 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Neuronal Cell Body Terminal Bouton Dendritic Spine Calyx Of Held Presynaptic Active Zone Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nucleus Nucleoplasm Nucleolus Dendrite
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Binding Purine Nucleoside Binding Protein Binding Heat Shock Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	DNA Binding RNA Binding Protein Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Neurological System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Heart Contraction Negative Regulation Of Hormone Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Fatty Acid Homeostasis Excitatory Postsynaptic Potential Relaxation Of Vascular Smooth Muscle Negative Regulation Of Mucus Secretion Triglyceride Homeostasis Regulation Of Cardiac Muscle Cell Contraction Apoptotic Signaling Pathway Negative Regulation Of Blood Vessel Diameter Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Adenosine P1 receptors G alpha (i) signalling events
Drugs		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
Diseases
GWAS		Asthma ( 31361310 30929738 27182965 31619474) Asthma (childhood onset) ( 31036433 30929738) Clozapine-induced agranulocytosis ( 25187353) Systolic blood pressure ( 30224653)	Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		11 interacting genes: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8	57 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HSFX1 MACROH2A1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8
Entrez ID		134	342371
HPRD ID		00042	19555
Ensembl ID		ENSG00000163485	ENSG00000224470
Uniprot IDs		B7Z1L9 P30542	P0C7T5
PDB IDs		5N2S 5UEN 6D9H
Enriched GO Terms of Interacting Partners?
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