ATXN1L and AFAP1L2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)

		ATXN1L	AFAP1L2
Description		ataxin 1 like	actin filament associated protein 1 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
Drugs
Diseases
GWAS		Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Metabolite levels ( 23823483) Systolic blood pressure ( 29212154)
Interacting Genes		57 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HSFX1 MACROH2A1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8	10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		342371	84632
HPRD ID		19555	13902
Ensembl ID		ENSG00000224470	ENSG00000169129
Uniprot IDs		P0C7T5	B7Z2Q0 Q8N4X5
PDB IDs			2COF
Enriched GO Terms of Interacting Partners?
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