TRIM6 and LGALS3

Number of citations of the paper that reports this interaction (PubMedID 27693506)
64

Data Source:
BioGRID (pull down)

		TRIM6	LGALS3
Description		tripartite motif containing 6	galectin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol	Immunological Synapse Extracellular Region Extracellular Space Nucleus Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Identical Protein Binding Ubiquitin Protein Ligase Activity Protein Tyrosine Kinase Binding	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Chemoattractant Activity Laminin Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Viral Process Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Stem Cell Differentiation	Monocyte Chemotaxis MRNA Processing RNA Splicing Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein Complex Assembly Regulation Of T Cell Proliferation Neutrophil Degranulation Innate Immune Response Regulation Of Myeloid Cell Differentiation Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling	Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs			2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058) Protein biomarker ( 23056639) Testicular germ cell tumor ( 28604728)
Interacting Genes		4 interacting genes: LGALS3 LGALS8 MYC TRIM5	25 interacting genes: APP C1GALT1C1 CSNK1A1 CSNK2A1 CSNK2A2 CUBN CYHR1 ELN FCGR2A GEMIN4 GOLGA2 LGALS3BP LIM2 MCPH1 MEFV MMP2 MYOC PPIG PRR13 SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6
Entrez ID		117854	3958
HPRD ID		12123	01090
Ensembl ID		ENSG00000121236	ENSG00000131981
Uniprot IDs		Q9C030	A0A024R693 P17931
PDB IDs			1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM
Enriched GO Terms of Interacting Partners?
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