CKS1B and CDC37

Number of citations of the paper that reports this interaction (PubMedID 19786724)
8

Data Source:
BioGRID (pull down)

		CKS1B	CDC37
Description		CDC28 protein kinase regulatory subunit 1B	cell division cycle 37, HSP90 cochaperone
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex
	Molecular Function	Protein Binding Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Cell Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression ERBB2 Signaling Pathway Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Fluoxetine Meta Vanadate
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 21833088)
Interacting Genes		32 interacting genes: AP2M1 ARID5A CBY2 CCNA1 CCNB2 CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 ECPAS HSP90AA1 IKZF1 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPTIN3 SKP2 SSBP1 SUMO1P1 TCF4 TRIM27 XIAP	75 interacting genes: A2M AKT1 APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 EIF2S1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MTOR MZT2B NCOA5 NOS3 NR2C2 OGA PPHLN1 PPP5C PRAM1 PRDX2 PRMT1 PSME1 PTGES3 RAD23A RAF1 RNF32 RPS15A SAFB SNX5 SPTBN4 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		1163	11140
HPRD ID		00299	05456
Ensembl ID		ENSG00000173207	ENSG00000105401
Uniprot IDs		P61024 Q5T178	A0A024R7B7 Q16543
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6	1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE
Enriched GO Terms of Interacting Partners?
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