MAL2 and GAD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAL2	GAD2
Description		mal, T cell differentiation protein 2 (gene/pseudogene)	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Membrane Cytosol Plasma Membrane Cell Junction Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding
	Biological Process	Myelination Transcytosis	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways			GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal Phosphate Glutamic Acid
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)	Lean body mass ( 28552196)
Interacting Genes		21 interacting genes: ABCG8 ARFIP2 CREB3 FAM3A GAD1 GAD2 NDRG4 PBX3 PIMREG PPP1CA PTPN9 RAB37 S100B SH3GL1 SHMT2 TBRG4 TPD52 TPD52L1 TPD52L2 TUBB VARS2	9 interacting genes: AGTRAP ARL6IP1 CMTM5 F10 GAD1 MAL2 PRKACA PRKCE TMEM159
Entrez ID		114569	2572
HPRD ID		14351	11817
Ensembl ID		ENSG00000147676	ENSG00000136750
Uniprot IDs		A0A024R9E4 Q969L2	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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