FDX2 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FDX2	LHX4
Description		ferredoxin 2	LIM homeobox 4
Image
GO Annotations	Cellular Component	Mitochondrial Matrix	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Sterol Metabolic Process Electron Transport Chain Small Molecule Metabolic Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Interacting Genes		2 interacting genes: APP LHX4	22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2
Entrez ID		112812	89884
HPRD ID		14465	03686
Ensembl ID		ENSG00000267673	ENSG00000121454
Uniprot IDs		Q6P4F2	A0A0S2Z5S4 Q969G2
PDB IDs		2Y5C	5HOD
Enriched GO Terms of Interacting Partners?
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