USP18 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		USP18	ISG15
Description		ubiquitin specific peptidase 18	ISG15 ubiquitin like modifier
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	Integrin Binding Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Regulation Of Inflammatory Response Regulation Of Type I Interferon-mediated Signaling Pathway	Integrin-mediated Signaling Pathway Viral Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Translesion Synthesis Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway Interleukin-10 Secretion Interferon-gamma Secretion
Pathways		ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488)
Interacting Genes		5 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 ZDHHC17	6 interacting genes: HDAC6 HIF1A SQSTM1 UBA7 USP18 USP21
Entrez ID		11274	9636
HPRD ID		06136	00958
Ensembl ID		ENSG00000184979	ENSG00000187608
Uniprot IDs		Q9UMW8	P05161
PDB IDs			1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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