DDX20 and LSM2

Number of citations of the paper that reports this interaction (PubMedID 10601333)
85

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DDX20	LSM2
Description		DEAD-box helicase 20	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane SMN Complex SMN-Sm Protein Complex RNA Polymerase II Transcription Repressor Complex Gemini Of Coiled Bodies	P-body Nucleus Nucleoplasm U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	DNA Binding RNA Binding RNA Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Protein Binding, Bridging Histone Deacetylase Binding Repressing Transcription Factor Binding	RNA Binding Protein Binding U6 SnRNA Binding Ral GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly RNA Processing Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Oogenesis Regulation Of Steroid Biosynthetic Process Import Into Nucleus	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		snRNP Assembly	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Body mass index ( 29273807) Metabolite levels ( 23823483)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)
Interacting Genes		33 interacting genes: AGO2 APP CRYAB DHX9 ETV3 GEMIN2 GEMIN4 GEMIN5 HDAC2 HDAC5 LSM2 NCOR1 NCOR2 NR0B2 NUFIP1 PRRC2A RN7SL1 RNU1-1 RNU2-1 SIN3A SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN STXBP2 STXBP3 TP53	33 interacting genes: BANP CLNS1A CRMP1 DDX20 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PNMA1 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408
Entrez ID		11218	57819
HPRD ID		05859	06282
Ensembl ID		ENSG00000064703	ENSG00000204392
Uniprot IDs		Q9H4N4 Q9UHI6	Q9Y333
PDB IDs		2OXC 3B7G	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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