TUBGCP2 and C1R

		TUBGCP2	C1R
Description		tubulin gamma complex associated protein 2	complement C1r
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Equatorial Microtubule Organizing Center Gamma-tubulin Complex Nucleoplasm Centrosome Microtubule Organizing Center Cytosol Cytoplasmic Microtubule Gamma-tubulin Small Complex Membrane	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Mitotic Cell Cycle Microtubule Nucleation Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle Microtubule Nucleation By Interphase Microtubule Organizing Center Protein-containing Complex Assembly	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc Human C1-esterase inhibitor Conestat alfa
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Mild influenza (H1N1) infection ( 26379185) Nonunion in individuals with fractures ( 30680360)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: ADAM12 BNIP3 C1R CALY CTSE H3C1 INPP5A KIF14 PCNT POLR2E UBC	8 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1 TUBGCP2
Entrez ID		10844	715
HPRD ID		18245	01954
Ensembl ID		ENSG00000130640	ENSG00000159403
Uniprot IDs		Q53EQ3 Q9BSJ2	P00736
PDB IDs			1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39
Enriched GO Terms of Interacting Partners?
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