C1R and PCK1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		C1R	PCK1
Description		complement C1r	phosphoenolpyruvate carboxykinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle	Cell Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response	Glucose Metabolic Process Pyruvate Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Internal Protein Amino Acid Acetylation Aging Response To Activity Propionate Catabolic Process Response To Lipopolysaccharide Response To Insulin Cellular Response To Insulin Stimulus Response To Lipid Glucose Homeostasis Response To Starvation Glycerol Biosynthetic Process From Pyruvate Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH Hepatocyte Differentiation Response To Interleukin-6 Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Methionine
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Zinc Human C1-esterase inhibitor Conestat alfa	Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine Phosphomethylphosphonic Acid-Guanylate Ester
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576)	Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Prudent dietary pattern ( 28644415) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1 TUBGCP2	6 interacting genes: APP C1R FBXO25 IKBKG RAE1 UBR5
Entrez ID		715	5105
HPRD ID		01954	02028
Ensembl ID		ENSG00000159403	ENSG00000124253
Uniprot IDs		P00736	P35558
PDB IDs		1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39	1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?
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