SH2B2 and EPOR

Number of citations of the paper that reports this interaction (PubMedID 10374881)
20

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SH2B2	EPOR
Description		SH2B adaptor protein 2	erythropoietin receptor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Type 2 diabetes ( 31049640)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		10603	2057
HPRD ID		16097	00587
Ensembl ID		ENSG00000160999	ENSG00000187266
Uniprot IDs		O14492	P19235
PDB IDs		1Q2H	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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