NPC2 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
17

Data Source:
BioGRID (two hybrid)

		NPC2	TRIM14
Description		NPC intracellular cholesterol transporter 2	tripartite motif containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Mitochondrial Outer Membrane
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Intermembrane Cholesterol Transfer Activity	Molecular_function Zinc Ion Binding
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport	Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Neutrophil degranulation LDL clearance	Interferon gamma signaling
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993)	Multiple sclerosis ( 31604244)
Interacting Genes		19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1	52 interacting genes: ABCF3 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H CENPC CSPP1 EIF3G ETFBKMT FAT1 HERC3 ITM2A IVNS1ABP KAT2B KIF3A LAMTOR1 MITD1 MNAT1 MRPL24 NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR2G PPP2R3C RAB5A RAB9A RBM33 RLF RNF125 RNF20 SMARCB1 SMIM3 STK38 TAX1BP1 TMEM167A UBE2B UBE2N UNK WDR35 WRNIP1 ZC4H2 ZFP36L2 ZNF652
Entrez ID		10577	9830
HPRD ID		03008	05948
Ensembl ID		ENSG00000119655	ENSG00000106785
Uniprot IDs		A0A024R6C0 P61916	A0A024R165 Q14142
PDB IDs		5KWY
Enriched GO Terms of Interacting Partners?
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