NPC2 and DHDDS

Number of citations of the paper that reports this interaction (PubMedID 15110773)
6

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NPC2	DHDDS
Description		NPC intracellular cholesterol transporter 2	dehydrodolichyl diphosphate synthase subunit
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Dehydrodolichyl Diphosphate Synthase Complex
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Intermembrane Cholesterol Transfer Activity	Polyprenyltransferase Activity Protein Binding Dehydrodolichyl Diphosphate Synthase Activity
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport	Dolichyl Diphosphate Biosynthetic Process Polyprenol Biosynthetic Process
Pathways		Neutrophil degranulation LDL clearance	Synthesis of Dolichyl-phosphate Defective DHDDS causes retinitis pigmentosa 59
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993)	FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1	3 interacting genes: LOX MT-ND1 NPC2
Entrez ID		10577	79947
HPRD ID		03008	12183
Ensembl ID		ENSG00000119655	ENSG00000117682
Uniprot IDs		A0A024R6C0 P61916	Q86SQ9
PDB IDs		5KWY
Enriched GO Terms of Interacting Partners?
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