SEC23B and UGT1A1

Number of citations of the paper that reports this interaction (PubMedID 9472029)
98

Data Source:
BioGRID (unspecified method)

		SEC23B	UGT1A1
Description		SEC23 homolog B, COPII coat complex component	UDP glucuronosyltransferase family 1 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Endoplasmic Reticulum Chaperone Complex Cytochrome Complex
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Positive Regulation Of GTPase Activity Cargo Loading Into COPII-coated Vesicle	Liver Development Bilirubin Conjugation Acute-phase Response Response To Nutrient Steroid Metabolic Process Estrogen Metabolic Process Drug Metabolic Process Animal Organ Regeneration Response To Lipopolysaccharide Heme Catabolic Process Retinoic Acid Metabolic Process Response To Starvation Negative Regulation Of Catalytic Activity Negative Regulation Of Steroid Metabolic Process Heterocycle Metabolic Process Flavone Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Biphenyl Catabolic Process Cellular Response To Ethanol Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways			Glucuronidation Defective UGT1A1 causes hyperbilirubinemia
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)	Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS			Bilirubin levels ( 22085899 19419973 23371916 20639394 19414484) Bilirubin levels in extreme obesity ( 25246029) Blood metabolite levels ( 24816252) Cholelithiasis-related traits in sickle cell anemia ( 22558097) Cholesterol, total ( 24097068) Circulating cell-free DNA ( 22511988) Hair greying ( 26926045) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Serum bilirubin levels in metabolic syndrome ( 30621171) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		21 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 NINL PRRC1 SEC24C SEC24D SKP1 SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 UGT1A1	3 interacting genes: COPZ1 SEC23B UGDH
Entrez ID		10483	54658
HPRD ID		11543	08933
Ensembl ID		ENSG00000101310	ENSG00000241635
Uniprot IDs		A0A2R8YFH5 Q15437	P22309 Q5DT03
PDB IDs
Enriched GO Terms of Interacting Partners?
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