HMG20A and SYTL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HMG20A	SYTL4
Description		high mobility group 20A	synaptotagmin like 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Protein Binding Phospholipid Binding Rab GTPase Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways			Platelet degranulation
Drugs			Insulin Human Insulin Pork
Diseases
GWAS		Hand grip strength ( 29691431) Hemoglobin A1c levels ( 29403010) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 21490949 22885922 24509480 30054458 22693455 21874001 30297969 30718926 28869590)	Lean body mass ( 28552196)
Interacting Genes		25 interacting genes: ADD1 BRAP CCDC136 CCNK CFAP53 DCTN4 DTNA DTNB FBXO7 FMNL1 GTF2A1L HMG20B HPCAL1 KPNA2 MAGOHB PHF21A PSTPIP1 PTH2R RBM7 RPP30 RSPH9 SCNM1 SMAD4 SYTL4 TESC	12 interacting genes: CCDC85B CEP70 FXR2 HMG20A INS RAB27A RAB27B RAB3A RAB8A STX1A STXBP1 ZBTB7B
Entrez ID		10363	94121
HPRD ID		16116	06735
Ensembl ID		ENSG00000140382	ENSG00000102362
Uniprot IDs		B4DMG1 Q9NP66	A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs			2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?
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