TFG and ARHGEF16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TFG	ARHGEF16
Description		trafficking from ER to golgi regulator	Rho guanine nucleotide exchange factor 16
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Endoplasmic Reticulum Exit Site	Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Cadherin Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling COPII Vesicle Coating	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		COPII-mediated vesicle transport	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases		Non-small cell lung cancer Thyroid cancer
GWAS			Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)
Interacting Genes		32 interacting genes: ANXA11 ARHGEF16 ARL15 BOLL CEP126 CEP55 CRMP1 CSTF2 ERG28 EWSR1 GBP2 GPRASP1 GRB2 HGS HNRNPF MAGED1 MAPK1IP1L MED21 MYOT PEF1 PIN1 PLSCR1 PTPN6 RBPMS RIPPLY2 SEC24A SPG21 STAT5B TOMM70 TRIM25 TSSK2 VPS37C	5 interacting genes: LMNA LNX1 MAPK1IP1L TFG YWHAQ
Entrez ID		10342	27237
HPRD ID		03932	12478
Ensembl ID		ENSG00000114354	ENSG00000130762
Uniprot IDs		Q05BK6 Q92734	B3KTS4 Q5VV41
PDB IDs			1X6B
Enriched GO Terms of Interacting Partners?
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