IKZF1 and DYRK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		IKZF1	DYRK2
Description		IKAROS family zinc finger 1	dual specificity tyrosine phosphorylation regulated kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Pericentric Heterochromatin Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding
	Biological Process	Chromatin Organization Cell Cycle Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 29296818) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 28552196) Hemoglobin levels ( 28017375) High density lipoprotein cholesterol levels ( 29403010) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 28453575 27863252 28017375 19862010) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Red blood cell count ( 29403010 27863252) Red blood cell traits ( 23222517) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010) Type 1 diabetes ( 25751624)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)
Interacting Genes		79 interacting genes: AEN ALKBH3 ANKRD11 AP1M1 AP2M1 ARMC7 BYSL C1orf109 C1orf174 C8orf33 CBX8 CDK2AP2 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 DCX DDB1 DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO3 LSM4 MAD2L2 MCRS1 MORF4L1 MORF4L2 MPPED2 NEK6 NME7 NOC4L NUDT21 PIN1 PNKP PRKAB2 PSMA1 PSMA4 RAD51D RBBP8 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPF SNW1 SPATC1L SYT17 TBP TDG UBE2I ZMAT2 ZNF417 ZNF581	22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		10320	8445
HPRD ID		04318	04606
Ensembl ID		ENSG00000185811	ENSG00000127334
Uniprot IDs		A0A2R8Y4D3 C9JTB0 Q13422 R9R4D9	Q92630
PDB IDs		6H0F	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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