CDK8 and MED25

Number of citations of the paper that reports this interaction (PubMedID 14983011)
61

Data Source:
HPRD (in vivo)

		CDK8	MED25
Description		cyclin dependent kinase 8	mediator complex subunit 25
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex	Nucleoplasm Mediator Complex Nuclear Transcription Factor Complex
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Alvocidib
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		29 interacting genes: BCL6 CCNC CCNH CDKN2B CTDP1 ERCC3 ESR1 ESR2 H3C14 MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77	14 interacting genes: CDK8 CREBBP CTDP1 HCFC1 MED1 MED15 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		1024	81857
HPRD ID		04422	14380
Ensembl ID		ENSG00000132964	ENSG00000104973
Uniprot IDs		P49336	M0QZQ2 Q71SY5
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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